郭亮
发布日期:2024-04-16   作者:yl7703永利官网  浏览数:950

姓名:郭亮

出生年月:19809

职称:副教授

邮箱:guoliang_xj@163.com


研究方向

1. 天然产物活性成分研究

2. 小分子结构修饰与活性研究


个人简介

郭亮男,汉族,现为yl7703永利官网应化系教师,20196月毕业于yl7703永利官网,获得工学博士学位,硕士生导师。


科研项目

1.基于不对称双-β-咔啉骨架的血管生成抑制剂的设计、合成及活性研究(22067017),2021-2024,国家自然科学基金项目,项目负责人。

2.基于Picrasidine G结构的双-β-咔啉衍生物的合成和活性测定(RCZK201933),2020-2023,yl7703永利官网高层次人才启动项目,项目批准号:项目负责人。

3.特色药材没食子黏膜炎症治疗系列产品的研发(2023AB047),2023-2025,兵团科技重大项目,子课题负责人。

4.西瓜甜瓜果实不同部位结构表征的差异性分析,横向课题,2023-2025,项目负责人。

5.β-咔啉酰胺类化合物(H-2-104)的合成与供应,横向课题,2023-2025,项目负责人。


代表性论文:

1.Zhu Siyu, Chen Xiaofei, Chen Wei, Ma Qin, Li Meng, Fan Wenxi, Zhang Jie* and Guo Liang*, Multicomponent synthesis of novel b-carbolinefused imidazolium derivatives via the Mannichreaction: cytotoxicity, molecular docking, andmechanistic studies as angiogenesis inhibitors. New J. Chem., 2022, 46, 4427–4435.

2. Ma Ling, Chen Xiaofei, Zhu Siyu, Chen Wei, Ma Qin, Fan Wenxi, Zhang Jie* and Guo Liang*, New β-carboline derivatives containingimidazolium as potential VEGFR2 inhibitors:synthesis, X-ray structure, antiproliferativeevaluations, and molecular modeling. RSC Med. Chem., 2022, 13, 1064–1076.

3. Guo Liang, Chen Xiaofei, Chen Wei, Ma Qin, Fan Wenxi, Zhang Jie*, Dai Bin*, Molecular hybrid design, synthesis, in vitro and in vivo anticancer evaluation, and mechanism of action of N-acylhydrazone linked, heterobivalent β-carbolines. Bioorg Chem.2020, 96, 103612.

4.Guo Liang, Chen Wei, Cao Rihui, Fan Wenxi, Ma Qin, Zhang Jie, Dai Bin*. Synthesis and structure-activity relationships of asymmetric dimeric β-carboline derivatives as potential antitumor agents. Eur. J. Med. Chem2018147, 253-265.

5.Guo Liang, Ma Qin, Chen Wei, Fan Wenxi, Zhang Jie, Dai Bin*. Synthesis and biological evaluation of novel N9-heterobivalent β-carbolines as angiogenesis inhibitors. J Enzyme Inhib Med Chem201934, 375-387.

6. Guo Liang, Xie Jianwei, Fan Wenxi, Chen Wei, Dai Bin*, Ma Qin. Synthesis and Antitumor Activities of Novel Bivalent 1-Heterocyclic-β-carbolines Linked by Alkylamino Spacer. Chin. J. Org. Chem201737, 1741-1747.

7. Guo Liang, Chen Wei, Fan Wenxi, Ma Qin, Sun Rongqin, Shao Guang, Cao Rihui. Synthesis and preliminary evaluation of novel alkyl diamine linked bivalent β-carbolines as angiogenesis inhibitors. Med. Chem. Commun20167, 2177-2183.


发明专利:

1.郭亮,王兆旭,马玲,张洁,杜灿,徐俊男;一种N-N桥连靛红单元的β-咔啉衍生物及其制备方法、应用;中国,ZL202310228794.62024.04.12

2.郭亮, 陈亮, 张洁, 和宇杰, 孙腾;种β-咔啉-3位连接1,2,3-三氮唑类化合物及其制备方法、应用;中国,ZL202310228788.02024.03.27

3.郭亮,马玲,张洁,王兆旭,陈双,张俊婷;一种N-N桥连噻唑单元的β-咔啉衍生物及其制备方法、应用;中国,ZL202310228786.12024.03.27

4.郭亮,张洁,朱思玉,代斌;一种β-咔啉杂合三唑类化合物及其制备方法、应用;ZL202110143623.42023.05.12

5.张洁,郭亮,李萌,陈晓飞,代斌;一种β-咔啉杂合咪唑类化合物及其制备方法、应用;ZL202110142794.52023.05.09