张洁-教授 硕士生导师
发布日期:2021-03-03   作者:研工办  浏览数:8277


基本情况:

张洁天津大学学博士,yl7703永利官网教授,硕士生导师。yl7703永利官网“3152”中青年骨干教师,优秀青年教师。


招生及研究方向:

化学(天然有机化学、有机小分子结构修饰及活性研究,1-2人)


讲授课程:

有机化学实验、高等有机化学药物合成


联系方式:

联系电话: 13579751798

邮箱:zhangjie-xj@163.com

地址:新疆石河子市北四路yl7703永利官网

邮编:832003


教育经历:

2000.9-2004.6 :yl7703永利官网,药学,理工学学士

2004.9-2007.6:yl7703永利官网,植物化学,理学硕士

2008.9-2011 .12:天津大学,应用化学,工学博士


承担科研项目:

1. 大蒜素原料药杂质制备与检测,企业委托,15万元,2021-2023,主持。

2. 抗包虫体内样品的合成(4),企业委托,11.6万元, 2020,主持。

3. 抗包虫候选药物H-2-168的中试合成工艺优化,yl7703永利官网创新发展项目,2019-2021,15万元,主持。

4. 抗包虫体内样品的合成(3),企业委托, 2019,8.4万元,主持。

5. 抗包虫体内样品的合成(2),企业委托, 2018,3.3万元,主持。

6. 去氢骆驼蓬碱结构改造与抗肿瘤活性研究,企业委托2016-2018,15.5万元 主持。

7. 抗包虫体内样品的合成,企业委托,2017-2018,3.2万元,主持。

8. 药西瓜中葫芦素类化合物的分离、纯化与活性研究(2013ZRKXYQ-YD01),优秀青年科技人才培育计划,2014-2015,主持。

9. 维药药西瓜化学成分的分离与抗肿瘤活性研究(RCZX201120),校高层次人才启动基金,2012-2013,

10.有机催化氰化反应研究(2011ZRKXTD-0404,校团队创新项目课题,2012-2014,主持


代表性论文:

1.Zhu Siyu,Huo Xinyu,Ma Qin,Chen Wei,Zhang Jie*, Guo, Liang*,Design, Synthesis, and Antitumor Activity of β-Carboline-Benzimidazole Hybrids, Chin. J. Org. Chem. 2022, 42, xxxx~xxxx. DOI: 10.6023/cjoc202110025

2.Sun, Yue, Guo, Liang, Fan, Wenxi, Chen, Wei, Zhang, Jie*, Dai, Bin. Synthesis, Crystal Structure and Antitumor Activity of Novel 5-Chloro-β-carboline Derivatives, Chin. J. Org. Chem. 2021, 41, 400-401. DOI: 10.6023/cjoc202006026

3.Liang Guo, Xiaofei Chen, Wei Chen, Qin Ma, Wenxi Fan, Jie Zhang*, Bin Dai*, Molecular hybrid design, synthesis, in vitro and in vivo anticancer evaluation,and mechanism of action of N-acylhydrazone linked, heterobivalent β-carbolines,Bioorganic Chemistry 96 (2020) 103612

4.孙跃,霍新玉,王兆旭,韩小强,张 洁*.苯并咪唑桥连的双-β-咔啉衍生物的合成与生物活性,精细化工,2020,08,1672-1677

5.Xiaofei Chen,Liang Guo,Qin Ma,Wei Chen,Wenxi Fan,Jie Zhang *, Design, Synthesis, and Biological Evaluation of Novel N-Acylhydrazone Bond Linked Heterobivalent β-Carbolines as Potential Anticancer Agents, Molecules 2019, 24, 2950

6.XinYu Huo, Liang Guo, XiaoFei Chen, YueTing Zhou, Jie Zhang *,XiaoQiang Han,* Bin Dai *,Design, Synthesis, and Antifungal Activity of Novel Aryl-1,2,3-Triazole-Carboline Hybrids, Molecules 2018, 23, 1344

7.Huo Xinyu, Li Wenbin, Zhang Boya, Chen Xiaofei, Zhou Yueting, Zhang Jie*,Han Xiaoqiang*, Dai Bin, Synthesis and Fungicidal Evaluation of Novelβ-Carboline-Benzimidazole and β-Carboline-Benzothiazole Hybrids, Chin. J. Org. Chem. 2018, 38, 3356-3362 DOI: 10.6023/cjoc201805053

8.Yueting Zhou, Chunjuan Wang, Fang Xin, Xiaoqiang Han*, Jie Zhang*, Ke Sun, Synthesis, Insecticidal, Fungicidal Activities and Structure–Activity Relationships of Tschimganin Analogs, Molecules 2018, 23, 1473

9.Xiaocong Sun, Feng Liu, Xueyuan Yang, Jinghan Wang, Bangjian Dong, Chunfeng Xie, Da-Qing Jin, Jie Zhang***, Dongho Lee, Yasushi Ohizumie, Jing Xu**, Yuanqiang Guo*. Seco-labdane diterpenoids from the leaves of Callicarpa nudiflora showing nitric oxide inhibitory activity, Phytochemistry, 2018, 149 : 31–41

10.周昌健, 谢建伟*, 张洁*, 代斌, 大黄酸-氨基酸缀合物的合成及初步抗肿瘤活性研究, 有机化学, 2017, 37(1): 122 ~ 132

11.张洁, 杜广芬, 顾承志*, 代斌, 氮杂环卡宾催化的氰基甲酸乙酯与醛亚胺的Strecker反应研究, 有机化学, 2017, 37(4): 914 ~ 919.

12.张洁, 周昌健, 谢建伟*, 代斌, 大黄酸-缬氨酸加合物的合成及初步抗肿瘤活性, 高等学校化学学报, 2016, (12): 2159 ~ 2167

13Jie Zhang, Ying Wang, Guangfen Du, Cheng-Zhi Gu*, Bin Dai, N-Heterocyclic Carbene-Catalysed Direct Synthesis of Cyano Esters via Cyanation- Esterification Reaction of α-Keto Esters, Chinese Journal of Chemistry, 2015, 33(10): 1211 ~ 1215

14.Zihao Li, Nannan Yan, Jianwei Xie*, Ping Liu, Jie Zhang*, Bin Dai, Efficient Copper-Catalyzed Annulation of 2-Formylazoles with 2-Haloanilines for the Synthesis of Pyrrole- and Imidazole-Fused Quinoxalines, Chinese Journal of Chemistry, 2015, 33(5): 589 ~ 593

15.Fei Song, Bin Dai, Haiyan Zhang, Jianwei Xie, Cheng-Zhi Gu, Jie Zhang*, Two new cucurbitane-typetriterpenoid saponins isolated from ethyl acetate extract of Citrullus colocynthis fruit, Journal of Asian Natural Products Research, 2015, 17(8): 813 ~ 818

16.Jie Zhang, GuangFen Du, YueKe Xu, Lin He*, Bin Dai*. N-Heterocyclic Carbene Catalyzed Cyanation Reaction of Carbonyl Compounds with Ethyl Cyanoformate and Acetyl Cyanide, Tetrahedron Letters, 2011, 52(52): 7153 ~ 7156


授权专利:

1.一种吲哚类化合物及其制备方法、应用,发明专利,ZL202010292093.5

2.一种6-取代-β-咔啉碱类化合物及衍生物的制备方法、应用,发明专利,ZL202010292093.5


科研奖励:

1.何林、杜广芬、顾承志、代斌、张洁、马晓伟、蔡志华,氮杂环卡宾催化的小环化反应研究,新疆兵团科技局,兵团科技进步奖,三等奖,2013